A comparison study on the multi-drug resistance of tuberculosis in Huzhou City

Objective To obtain the data on total drug resistance rate,initial drug resistant rate and acquired drug resistant rate and to analyze the efficacy of modern tuberculosis control strategy in Huzhou City. Methods Collect sputum specimens which were cultured positive from mycobacterium tuberculosis patients with new registration and identification in Huzhou in the first stage( 2001—2004) and second stage( 2009—2010). The sample size was 192 and 772 respectively. We used cultured positive specimens for drug sensitivity test which was by means of proportion method. Results In the first stage( 2001—2004),the rate of total drug resistance,multi-drug resistance,initial resistance and acquired resistance was 25. 25%,6. 9%,19. 02% and 51. 30% respectively. The rates above in the second stage( 2009—2010) were 15. 41%,3. 50%,11. 95% and 43. 02% respectively. There was significant difference( P 0. 01) in the rates of total drug resistance,multi-drug resistance and initial resistance between the two stages,but no significant difference( P 0. 05) in the rate of acquired resistance. Conclusion Modern tuberculosis control strategy makes noticeable achievements for the drug resistant tuberculosis control,but the acquired drug resistance remains to be the focus of tuberculosis prevention and control in the current strategy.