Prevalence survey and analysis of drug-resistant tuberculosis

Objective To study the prevalence of drug-resistant tuberculosis and to provide effective and scientific basis for prevention and control of drug-resistant tuberculosis.Methods Monitoring-stations were set up in counties and districts of certain city between March 2012and March 2013.A total of 164pulmonary tuberculosis patients,whose sputum smears were with positive diagnosis,were selected as research objects by random sampling for drug susceptibility test and data analysis.Results Drug-resistant rate to first-line drugs,such as isonicotinyl hydrazide(INH),rifampicin(RFP),ethambutol(EMB)and streptomycin(SM),of tuberculosis patients with initial treatment was significantly lower than that of patients with re-treatment(P0.05).But only two kinds of multi-drug resistance were identified,including resistance to INH,RFP,EMB,and resistance to INH,RFP,SM,EMB,and the multi-drug resistance rates were with significant difference between patients with initial treatment and patients with re-treatment(P0.05).Drug-resistance rate of tuberculosis patients with initial treatment to SM was the highest(23.86%),but of patients with re-treatment,resistance rate to INH was the highest(42.11%),and there was significant difference between the two groups(χ 2=5.38,P0.05).Conclusion The status of drug resistance of tuberculosis in this city should be targeted improved to inhibit the prevalence of drug-resistant tuberculosis.