Clinical effect of edaravone combined with nimodipine in the treatment of the non-operative cerebral contusion and laceration

Objective To explore the clinical effect of edaravone combined with nimodipine in the treatment of cerebral contusin and laceration. Methods Ninety-seven patients with the non-operative cerebral contusin and laceration in our hospital from Sep. 2010 to Mar. 2012 were divided into the study group (n=49) and the control group (n=48). Patients in the control group were treated with nimodipine pumped into the vein, while those in the study group were given edaravone daily in static drops based on the control group. Five days after treatment, the clinical efficacy and clinical neurological defect were scored. CT examinations were performed on the third and fifth day after treatment. The changes in cerebral edema volume were compared between the two groups. Results The clinical efficacy of the study group was significantly better than that in the control group (with the total effective rates 95.9% and 83.3%, respectively, P0.05). The clinical neurological defect scores were significantly improved in the study group than the control group (t=2.357, P0.05). The brain edema significantly less serious in the study group (t=2.436, P0.05). Conclusion In the treatment of the non-operative cerebral contusion and laceration, edaravone combined with nimodipine can help clear away free radical, reduce cerebral edema, and improve patients’ symptoms and the curative effect.