The Expression of Lung Resistance Protein in Endometrial Carcinoma and Its Clinical Significance

Objective To study the effect of lung resistant protein(LRP) on treatment in endometrial carcinoma and its relation to prognosis.Methods The LRP expression of 30 cases of paraffin embedded endometrial carcinoma specimens were measured with immunohistological staining SP.The postoperational chemotherapeutic results of these cases were analyzed.Results ①The positive rate of LRP expression was 80 %(24/30). ②The effective rate of chemotherapy in patients with positive LRP expression was 45.8 % which was significantly lower than that in patients with negative LRP expression(83.3 %). ③The expression of LRP was associated with the occurrence of ascites,but not associated with age of patient,clinical staging and histological grad. ④The prognosis of patients with negative expression of LRP was significantly better than those with positive expression. Conclusions It is demonstrated that LRP is a reliable index for evalution the drug resistance in chemotherapy and prognosis.