Study on correlation among expression of LRP and platinum resistance and prognosis in advanced non-small cell lung cancer

Objective To study the expression of lung resistance protein( LRP) in non-small cell Lung Cancer( NSCLC) and its correlation with Platium resistance and prognosis. Methods The expression of LRP in 89 NSCLC patients was detected by the way of immunohistochemical method. The relationship between LRP and clinicopathological feature and the others( age,sex,smoking history,histological type,differentiation,distant metastasis, lymphatic metastasis and so on) were studied. Results In the tissues of patients with NSCLC,the positive expressing rate of LRP was 77. 5%,and was not related with age,sex,smoking history,histological type,differentiation, distant metastasis,lymphatic metastasis( P 0. 05). In the platinum contained chemotherapy regimens,there were not statistical significant difference in RR,DCR,PFS,and OS between the LRP positive expression group and the LRP negative expression group( all P 0. 05). The positive expression rate of LRP in female patients( 95. 5%) was higher than that in male patients( 71. 6%; P = 0. 043). The positive expression rate in the patient with distant metastasis( 87. 3%) was higher than that in the patients without distant metastasis( 61. 8%)( P = 0. 005). Conclusion The positive expression of LRP is related to the diagnosis distant metastasis of NSCLC. The PFS,OS in LRP-positive patients are lower than those in LRP negative patients. These results suggest LRP may be an evaluating indicator of the prognosis of NSCLC.