Research of the relationship between the clinical effects of paclitaxel liposome with DDP and expression of lung cancer resistance protein genes(LRP) in non-small cell lung cancer

Objective To investigate the relationship between the expression level of lung cancer resistance protein(LRP) and the clinical effects on non-small cell lung cancer(NSCLC) tissues by bronchoscopy biopsy.Methods The expression of LRP was detected in 47 cases of NSCLC tissues through bronchoscopy biopsy or lymphaden biopsy tissues by streptavidin-biotin-peroxidase(S-P) immunohistochemistry technique,and observed the relationship between the expression level of LRP and their clinical effects after two cycles' chemiotherapy treated by TP regimen.Results The positive expression rates of LRP on NSCLC was 61.70%.The positive expression positive rates of LRP in the adenocarcinoma and squamous carcinoma were 76.92% and 42.86% respectively.There was statistic difference in LRP expression compared with adenocarcinoma and squamous carcinoma(P0.05).No significance of difference was observed in LRP positive expression rates in different TNM staging of lung cancer(P0.05).The total clinical effective rates was 42.55% after two cycles chemiotherapy treated by TP regimen and the clinical effective rates were 27.59% and 66.67% respectively between the positive expression of LRP and negative expression of LRP,and there was statistic difference in those two groups(P0.01).Conclusion There was different degree expression of LRP in NSCLC and also statistic difference in LRP expression level compared with adenocarcinoma and squamous carcinoma,as well as in clinical effects after treated with TP regimen.There was statistic difference between the negative expression of LRP and positive expression of LRP.