Study on amiodarone plus irbesartan in treatment of paroxysmal auricular fibrillation

Objective: To evaluate the clinical efficacy of irbesartan plus amiodarone on maintenance of sinus rhythm in patients with paroxysmal auricular fibrillation (PAF). Methods: 110 patients with PAF were randomly divided into two groups: group I (n=55) was treated with amiodarone alone; group Ⅱ (n=55) was treated with amiodarone plus irbesartan. The left atrial diameter (LAD)was measured with transthoracic echocardiogram 6, 12, 18 and 24 months before and after treatment. The follow-up study was two years and the primary end point of the study was the first recurrence of auricular fibrillation ( AF). Results: After 12 months of treatment, LAD in group I was significantly larger than that in group Ⅱ (P0.05). At the end of the study, the sinus rhythm maintenance of group I was lower significantly than that of group Ⅱ. (58.18% vs 78.18%, P0.05). Conclusions: Amiodarone plus irbesartan, in maintenance of sinus rhythm, for patients with paroxysmal auricular fibrillation is superio to amiodarone alone.They can inhibit the enlargement of left atrium and reduce recurrence rate in patients with PAF.