Changes of Serum oxLDL-Ab and hs-CRP Levels and Their Relationship in Patients with Coronary Heart Disease

Objective To investigate the changes of serum anti-oxidized LDL autoantibodies(oxLDL-Ab)and high-sensitivity C-reactive protein(hs-CRP) and their relationship in patients with coronary heart disease (CHD).Methods Serum samples were taken from 152 patients with CHD and 90.healthy subjects.The serum levels of oxLDL-IgG、oxLDL-IgM and hs-CRP were quantitatively measured by radioimmunoassay and immunonephelometry assay.Results The serum levels of oxLDL-IgG、oxLDL-IgM and hs-CRP were greatly elevated in patients with CHD as compared with healthy subjects [(6.46±3.70)g/L、(2.65±0.83)g/L and (5.28±1.25)mg/L vs (3.19±0.92)g/L、(0.82±0.27)g/L and (1.74±0.41) mg/L,P0.01)]. There was no significant correlation between the serum level of oxLDL-Ab including oxLDL-IgG and oxLDL-IgM and the serum level of hs-CRP in patients with CHD and healthy subjects(r=-0.113～0.102,P0.05).Conclusion oxLDL-Ab and hs-CRP were closely correlated with the formation of CHD and they both maybe independently played important roles in the process of development of atherosclerosis.