Study on Expression of NF-κB in Cervical Carcinoma

Objective:To evaluate the significance of nuclear factor(NF)-κB expression in cervical cancer.Methods:The expression of NF-κB protein was analyzed by immunohistochemistry S-P method.Results:The positive expressions of NF-κB were 74.1%(30/42) in 42 patients with cervical cancer,15%(3/20) in 20 cervical intraepithelial neoplasia(CIN) and non in normal cervical tissue.The significant differences of NF-κB expression were observed between cervical cancer,CIN and normal cervical tissues(P 0.05).But there was no significant difference between CIN and normal cervical tissues(P 0.05).In cervical cancers,NF-κB expression was not associated with age and pathologic types(P 0.05).The expression of NF-κB was higher in the patients with poorly differentiated,stage Ⅲ-Ⅳ and positive pelvic lymph nodes metastasis than that of patients with good differentiated,stage Ⅰ-Ⅱ and negative pelvic lymph nodes metastasis(P 0.05).Conclusion:Abnormal expression of NF-κB may be one of the important mechanisms in the cervical carcinogenesis and progression.