The expression and clinical significance of nm23-H1 protein in cervical intraepithelial neoplasia and cervical cancer

Objective To investigate the roles of anti-metastasis gene-nm23-H1 protein(non-metastatic protein 23 homologue 1) in the tumorigenesis,progress and prognosis of cervical cancer by observing its expression in cervical intraepithelial neoplasia and cervical squamous cell carcinoma.Methods The expression of nm23-H1 protein was detected by immunohistochemistry(SP) method in 60 cases of squamous cell carcinomas,60 cases of cervical intraepithelial neoplasia(20 CINⅠ,20 CINⅡand 20 CINⅢ,respectively) and 20 cases of normal cervical tissues,and the clinicopathological significance of the nm23-H1 protein expression was analyzed.Results The positive expression rate of nm23-H1 protein in cervical cancer tissues was significantly lower than that of normal cervical tissue,especially in CINⅠand CINⅡ(P0.05).The positive expression rate of nm23-H1 protein in CINⅢ was lower than that in cervical cancer tissues,however,there was no significant difference between them(P0.05).The expression of nm23-H1 in cervical cancer tissues was closely correlated with lymph node metastases and FIGO stages(P0.05),however,which was not related with patients' age,histopathological grades and tumor size(P0.05).Conclusion The low expression of nm23-H1 protein is a high risk factor of cervical cancer,which is a significant index for evaluating lymph node metastases and patients' prognosis in patients with cervical cancer.