Detecting significance of serum high sensitivity C-reactive protein in coronary heart disease

Objectives To study the changes and significance of the levels of serum high sensitivity C-reactive protein (hs-CRP) in coronary heart disease. Methods 138 patients of coronary heart disease were randomly recruited, including 43 cases of a-cute myocardial infarction ,45 unstable angina and 50 stable angina,and 50 healthy persons recruited as control group. Their levels of serum hs-CRP were determined by scatter velocity turbidimetry. Results There were significant differences between the levels of serum hs-CRP in the patients with acute myocardial infarction, unstable angina, stable angina and control group (P0.001). the 25 percentile of serum hs-CRP was 2.61mg/L, that with the 50 percentile 9.50mg/L, and the 75 percentile 33.4mg/L respectively. It was showed significantly different distribution between the levels of serum hs-CRP in coronary heart disease group and the control group(P0.001). There were no differentces among the patients with coronary heart disease(P0.05). Conclusions The patients with coronary heart disease have higher levels of serum hs-CRP. The serum hs-CRP can be regarded as a independent risky factor of the cardiovascular disease as well as a prediction of the coronary heart disease.