Clinical Observtion of Kanglao Decoction Assisted with Chemotherapy for Treatment of Multi-drug Resistant Tuberculosis in 50 Patients

Objective: To observe the curative efficacy of syndrome dependent Kanglao decoction combined chemotherapy in treating multi-drug resistant tuberculosis( MDR-TB),and to investigate its influence on cellular immune regulation. Method: One hundred patients with MDR-TB were randomly divided into the control group( 50 cases) and the observation group( 50 cases) by a random number table. According to the different situation,patients in the control group received conventional chemotherapy. Based on the treatment of the control group,patients in the observation group added modified Kanglao decoction. All patients in two groups received 6months of treatment. Sputum negative conversion and situation of computed tomography( CT) X-ray absorption were observed,and scores of traditional Chinese medical( TCM) syndrome were recorded. Before and after treatment,levels of T lymphocyte subsets( CD3+,CD4+,CD8+) were detected,blood routine of kidney and liver function were monitored. Adverse reaction was recorded during the treatment. Result: The comprehensive curative effect of the observation group was superior to that of the control group( P 0. 05). Sputum negative conversion rate was 88% in the observation group,which was better than that of 62% in the control group during 6 months of treatment( P 0. 05). The curative effect of chest CT in the observation group was 90%,which was superior to that of 64% in the control group during 6 months of treatment( P 0. 05). Symptom score of TCM in the observation group was lower than that in the control group after 2,4,6 months of treatment( P 0. 01). Levels of CD3+,CD4+in the observation group were higher,while CD8+standard was lower than those in the control group( P 0. 01). The incidence of liver damage and leukopenia in the observation group was less than those in the control group( P 0. 05). Occurrence frequency of side effects on digestion system,skin system,nerve system,etc,in the observation group were inferior to those in the control group( P 0. 01). Conclusion: Kanglao decoction assisted with chemotherapy drugs could reduce sputum negative conversion,improve chest CT absorption,relieve clinical symptoms and side reaction,enhance organism cellular immunity function in treating MDR-TB. Its clinical comprehensive efficacy is superior to using Western medicine treatment alone.