Effects of the simvastatin treatment on the elderly patients with primary hypertention

Objective To investigate the effect of simvastatin treatment on the elderly patients with primary hypertension(PH) .Methods Sixth-six elderly PH patients were treatment with Amlodipine(5 mg/d) .After the blood presuee were decreased to mild hypertension level,all the patients were randomly divided into 2 groups:36 patients in the simvastatin group,and 30 patients in the control group.The patients in the control group were treated with low fat and low salt diet and Amlodipine as before,and the patients in the simvastatin group were treated not only with simvastatin 10 mg once a day and Amlodipine as before for 12 weeks.Results The SBP and pulse pressure(PP) were improved in both simvastatin and control groups,and simvastatin showed a better therapeutic effect,There were signicant differences between the two groups(P 0.05) then did the control.simvastatin group had SBP of(148±8,pretreatment) and(132±7,pretreatment) ,and PP of(64±9,pretreatment) and(49 ±9,posttreatment) ,There were signicant differences between the two groups(P0.05) .Control group showed SBP of(146±10) and(146±9) in pre-and post-treatment respectively,and showed PP of(63±10,pretreatment) and(63±9,posttreatment) (P0.05) .Conclusion Anti-hypertensive medications in a routine dose combined with simvastatin have a better effect on the hypertension treatment in elderly patients.