Therapeutic effect of losartan on hypertension patients associated with hyperuricemia

Objective To study the effects of treating uricacidemia and anti hypertension by losartan in patients with hypertension associated hyperuricemia.Methods Selected 68 patients with hypertension and hyperuricemia,in which divided two groups by random,one group with losartan 50 mg per day po,other group with captopril 25 mg per day po,the drug dose can be changed according the level of the blood pressure,for 4 weeks,compared the changes of serum uric acid and the blood pressure for two groups.Results ①The systolic blood pressure and diastolic blood pressure decreased prominently in both groups after four weeks treament(P0.01),but there was no significant difference between losartan group and captopril group(P0.05);②The serum uric acid had apparently reduced in losartan group after four weeks treatment(P0.05),while there was not significantly reduced in captopril group(P0.05);③There was no significant side effect between losartan group and captopril group.Conclusion Losartan can drecrease the level of the blood pressure and serum uric acid,which is effective and safe for essential hypertension patients with hyperuricemia using losartan to control the blood pressure.