2010•Journal of Nongken MedicineRequires access

Studies on the Preparation of Harmine Solid Lipid Nanoparticles

Weijun Chen

Abstract

Objective: To prepare the Harmine solid lipid nanoparticles(HM-SLN).Methods:The preparation of HM-SLN was optimized by orthogonal design with the encapsulate efficiency(EE%),drug loading(DL%) and stability as evaluation parameters.Then the quality of the obtained HM-SLN was determinated.Results:The obtained HM-SLN had even with a mean diameter of 121 nm,the encapsulate efficiency ratio and the drug loading of the prepared HM-SLN was(88.11±0.585)% and(2.03±0.005)%.Conclusion:The entrapment ratio of HM-SLN is high and the stability is good for HM-SLN prepared by twice high shear ultrasound method,and the method is reliable.

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Key concepts: Solid lipid nanoparticle, Harmine, Chromatography, Materials science, Chemistry, Nanoparticle, Nuclear chemistry, Biomedical engineering