2008•Di-san junyi daxue xuebaoRequires access

Formulation and preparation of glycyrrhizic acid solid lipid nanoparticles

Shiwen Zhou

Abstract

Objective To prepare the glycyrrhizic acid solid lipid nanoparticles(GL-SLN).Methods GL-SLN was prepared by conventional rotary-evaporated film-ultrasonication method.Based on the single-factor experiment,GL-SLN was prepared using orthogonal design for optimization of formulation and technology.The obtained GL-SLN was also evaluated.Results GL-SLN had even and regular appearance and the average diameter was 75.8 nm.Zeta potential was-19.7 mV.The drug loading was 8.27% and the entrapment ratio was 91.76%.Conclusion The entrapment ratio of GL-SLN and the stability of GL-SLN prepared by conventional rotary-evaporated film-ultrasonication method are high and good.

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Available abstract

Key concepts: Solid lipid nanoparticle, Sonication, Zeta potential, Entrapment, Chromatography, Chemistry, Materials science, Nanoparticle