2008•Zhongguo yaofangRequires access

Optimization of the Preparation Technology of Berberine Hydrochloride Solid Lipid Nanoparticles by Orthogonal Experiment

Shiwen Zhou

Abstract

OBJECTIVE: To prepare Berberine hydrochloride solid lipid nanoparticles(BH-SLN). METHODS: BH-SL-N was prepared by conventional rotary-evaporated film-ultrasonication method. Based on the single-factor experiment, BH-SLN was prepared using orthogonal design for optimization of formulation and technology. The quality of the obtained BH-SLN was evaluated. RESULTS:BH-SLN had even and regular appearance with a mean diameter of 60.5 nm,Zeta potential of —29.7 mV,drug loading of 8.69%, and entrapment ratio of 97.58%. CONCLUSION: The entrapment ratio of BH-SLN is high and the stability is good for BH-SLN prepared by conventional rotary-evaporated film-ultrasonication method, and the method is reliable.

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Key concepts: Solid lipid nanoparticle, Sonication, Zeta potential, Berberine hydrochloride, Materials science, Chromatography, Hydrochloride, Chemistry