Comparative Study on the Pharmacokinetics of Paeonol in Cynanchum Paniculatum and Paeonol Injection in Rabbit's Body

Objective This paper has developed a method of determining the content of paeonol in rabbit's plasma by carrying out a comparative research on the pharmacokinetics of paeonol in Cynanchum paniculatum and paeonol injection in rabbit plasma.Methods The rabbits were divided into several groups at random,and they were injected respectively i.g Cynanchum paniculatum 6mg·kg-1 and i.m 0.96mg·kg-1 paeonol.The blood density at different intervals was tested by high performance liquid chromatography(HPLC).The parameters of pharmacokinetics were calculated by 3P87 pharmacokinetic program. Results The pharmacokinetic profiles conformed to a one-compartment model after injection into stomach.i.g,The mian Pharmacokinetic parameters: t1/2(α)= 0.174h,t1/2(e)= 0.796h,Tmax=0.489h,Cmax=0.225μg·mL-1,AUC=0.395μg/mL·h.The pharmacokinetic profiles followed a two-compartment model after injection into muscle.The main pharmacokinetic parameters: T1/2(α)= 0.112h,T1/2(β)= 1.417h,Tmax=0.179h,Cmax=0.439μg·mL-1,AUC=0.546μg/mL·h,CL=8.832 L·h-1.Conclusions Paeonol is quickly spread and eliminated.Pharmacokinetics processes of Paeonol differ in terms of two methods of injecting medicine.It is obvious that injection into muscle is superior to giving medicine to stomach.