Pharmacokinetics of Funingkang Paoteng capcule
Jin Su
Abstract
Jin Su
Abstract
Objective To study the pharmacokinetics of Fujingkang Paoteng capcule in rabbit body.Methods Used HPLC method for the determination of Glycyrrhizic acid in rabbit body 48 h plasma concentration.The pharamacokinetic parameters were fitted by 3P87.Result The main parameters were as follows: t1/2=8.956 h,Tmax=8.27 h,Cmax=0.4544 μg/ml,AUC=37.161.Conclusion The preparation in rabbit body absorption and elimination were slower.Its biological half-life was more than 8 hours.
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Objective To study the pharmacokinetics of Fujingkang Paoteng capcule in rabbit body.Methods Used HPLC method for the determination of Glycyrrhizic acid in rabbit body 48 h plasma concentration.The pharamacokinetic parameters were fitted by 3P87.Result The main parameters were as follows: t1/2=8.956 h,Tmax=8.27 h,Cmax=0.4544 μg/ml,AUC=37.161.Conclusion The preparation in rabbit body absorption and elimination were slower.Its biological half-life was more than 8 hours.
Key concepts: Pharmacokinetics, Cmax, Chemistry, Plasma concentration, High-performance liquid chromatography, Chromatography, Absorption (acoustics), Pharmacology