2007•Zhongguo weishengtaixue zazhiRequires access

Pharmacokinetics of Funingkang Paoteng capcule

Jin Su

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Abstract

Objective To study the pharmacokinetics of Fujingkang Paoteng capcule in rabbit body.Methods Used HPLC method for the determination of Glycyrrhizic acid in rabbit body 48 h plasma concentration.The pharamacokinetic parameters were fitted by 3P87.Result The main parameters were as follows: t1/2=8.956 h,Tmax=8.27 h,Cmax=0.4544 μg/ml,AUC=37.161.Conclusion The preparation in rabbit body absorption and elimination were slower.Its biological half-life was more than 8 hours.

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Objective To study the pharmacokinetics of Fujingkang Paoteng capcule in rabbit body.Methods Used HPLC method for the determination of Glycyrrhizic acid in rabbit body 48 h plasma concentration.The pharamacokinetic parameters were fitted by 3P87.Result The main parameters were as follows: t1/2=8.956 h,Tmax=8.27 h,Cmax=0.4544 μg/ml,AUC=37.161.Conclusion The preparation in rabbit body absorption and elimination were slower.Its biological half-life was more than 8 hours.

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Available abstract

Objective To study the pharmacokinetics of Fujingkang Paoteng capcule in rabbit body.Methods Used HPLC method for the determination of Glycyrrhizic acid in rabbit body 48 h plasma concentration.The pharamacokinetic parameters were fitted by 3P87.Result The main parameters were as follows: t1/2=8.956 h,Tmax=8.27 h,Cmax=0.4544 μg/ml,AUC=37.161.Conclusion The preparation in rabbit body absorption and elimination were slower.Its biological half-life was more than 8 hours.

Key concepts: Pharmacokinetics, Cmax, Chemistry, Plasma concentration, High-performance liquid chromatography, Chromatography, Absorption (acoustics), Pharmacology

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