Pharmacokinetic study on compatibility injection of honeysuckle and forsythia suspense in rabbits

To provide theory evidence for compatibility between honeysuckble and forsythiae,the pharmacokinetics process of chlorogenic acid and phillyroside in the rabbit were studied by detecting the contents of chlorogenic acid and phillyroside of honeysuckble injection(A group),forsythia suspense injection(B group),confuse injection(C group),mix the single injection(D group) by HPLC.Through A,C,D groups im injections,chlorogenic acid pharmacokinetics process in rabbit is two-compartment model,and the major pharmacokinetics parameters are:Cmax of A,B,C groups is 1.567,1.656,1.612 g·L-1;Tmax is 0.413,0.224,0.285 h;Tβ/2 is 1.164,1.227,1.132 h;AUC is 1.905,2.623,2.114 mg·h ·L-1.Through B,C,D groups im injection,phillyrins pharmacokinetics process in rabbit is one-compartment model,and the major pharmacokinetics parameters of phillyrin are:Cmax of B,C,D injection is 1.548,1.902,1.576 mg·L-1;Tmax is 0.742,0.606,0.646h;Tβ/2 is 1.272,1.212,1.220 h;AUC is 2.80,3.216,2.881 mg·h ·L-1.The results show that compatibility can reduce the Tmax of chlorogenic acid;mixed decoction can improve Cmax of phillyroside;compatibility and mixed decoction can improve AUC of chlorogenic acid and phillyroside,indicating that compatibility between honeysuckble and forsythiae has its theory basis.