Pharmacokinetic Features and Absolute Bioavailability of Paeonol in Conscious Rat

Objective To study pharmacokinetic features of paeonol after intragastric(ig)and intravenous(iv)administration to conscious.Methods Paeonol was administered ig and iv in single dose(10 mg/kg).Blood samples were collected at intervals after each administration.Plasma concentration of paeonol was detected by HPLC.Pharmacokinetic parameters were calculated by pharmacokinetic program DAS 2.0 in which noncompartmental model was chosen.Results Pharmacokinetic parameters for paeonol following intragastric and intravenous administration in conscious rat were as follows: AUC0-∞ were(18.13± 4.78) and(62.70± 6.05)mg·L-1·min-1.t1/2z were(23.37±8.73)and(52.01±11.70)min.MRT0-∞ were(28.07±8.68)and(47.37±7.45)min.After intragastric administration,Tmax and absolute bioavailability were(5.0± 0.0)min and 28.92%.Conclusion Pharmacokinetic processes of paeonol are different after administered ig or iv.Absolute bioavailability of paeonol for ig is low.