Drug resistance of Escherichia coli and Klebsiella pneumoniae and analysis of ESBLs-producing strains

OBJECTIVE To analyze the clinical isolation and drug resistance of Escherichia coli and Klebsiella pneumonia that were isolated from Hongqi Hospital in 2010 so as to provide basis of the reasonable clinical medication.METHODS The identification and antibiotic susceptibility testing of the bacteria were determined by microorganism analyzer in all the specimens from clinical departments.ESBLs-producing strains were confirmed with double disc method.RESULTS A total of 80 strains E.coli were isolated in 2010,among which there were 19 strains of ESBLs-producing E.coli with the positive rate of 23.8%,and 89 strains of K.pneumonia were isolated,among which there were 19 strains of ESBLs-producing K.pneumoniae with the positive rate of 21.3%.The drug resistance rates of the ESBLs-producing E.coli and K.pneumoniae to imipenem and meropenem were 0%.The drug resistance rate of the ESBLs-producing strains to most antibiotics was significantly higher than that of the non-ESBLs-producing strains.CONCLUSION The detection rate of the clinically isolated ESBLs-producing strains is increasiny,the drug resistance rate of which is higher than that of the non-ESBLs-producing strains.The isolated strains are multidrug-resistant,which bring great difficulties to the clinical treatment.It is necessary to strengthen the monitoring of drug resistance of the ESBLs-producing strains and guide the reasonable clinical medication so as to prevention the prevalence and spread of the ESBLs-producing strains.