Analysis of risk factors of multi-drug resistant tuberculosis in Urumqi

Objective To investigate resistance of 4 anti-tuberculosis drugs to tuberculosis in Urumqi, and to analyze the risk factors of causing drug resistance. Methods Samples of tuberculosis patients treated in CDCs of seven districts and one county in Urumqi during May 1st, 2011 to September 30, 2012. Specimens were cultured with improved L-J medium,and the positive cultured strains were taken sensitivity test with 4 antituberculosis drugs. The drug resistance and risk factors of causing drug resistance were analyzed statistically. Results Drug sensitivity test were carried out in 259 pulmonary tuberculosis patients, with all sensitive to the drugs of 188 patients, multiple drug resistance of 20 cases and multiple drug resistance rate of 7.72%, including resistant rate of 8.44% of the male, and 6.67% of the female. The difference in multiple drug resistance rate was of no statistical significance(P0.05) among gender(c2=0.41), nationalities(c2=0.13), census register(c2=0.77), age(c2=0.89), occupation(c2=6.47) and HIV detection(c2=1.23). The multiple drug resistance correlated closely with therapeutical history, with statistical significance(OR=9.00, P0.05). The risk of multiple drug resistance of retreatment was9.00 times of that of initial treatment. Conclusions The patients accepted initial treatment must be taken effective therapy management so as to ensure regular treatment and decrease multiple drug resistance. Drug sensitive test should be carried out as much as possible in the retreatment patients, and individualized treatment must be performed based on drug sensitive test results.