Analysis on the monitoring results of drug resistance of the tuberculosis in Shenzhen City in 2008

Objective To study the present status of drug resistance in tuberculosis (DR-TB) and find factors contribute to drug resistance and to control DR-TB effectively.Methods According to the guideline for Surveillance of Drug Resistance in Tuberculosis (WHO/IUALD),all new smear positive cases and new registered retreatment smear positive cases in 2008 were studied.Drug susceptibility was tested by the proportion method.The information was collected through questionnaires.Univariate analysis and multivariable logistic regression analysis were used to find the risk factors on developing anti-TB drugs.Results (1) Among 769 clinical isolated strains,759 cases were Mycobacterium tuberculosis.The total rate of DR-TB in 759 cases was 20.2% and the multi-drug resistance rate was 5.1%.87.6%(134/153) of DR-TB patients were floating population,and 79.1%(121/153) of them were the initially treated cases.(2) By Chi-square test,there was a significant difference between new and re-treatment patients on drug resistance (χ2=15.632,P0.001).The linear trend test showed that there was a linear relationship between Body Mass Index (BMI) and Drug resistance (χ2=4.403,P0.05).(3) The binary logistic stepwise regression analysis demonstrated that the treatment class,BMI and family contacting integrate into the regression equation.Conclusions The drug resistance rate of pulmonary tuberculosis of Shenzhen was high in 2008.The re-treatment patients had higher risk to develop anti-TB drug resistance,and DR-TB control in Shenzhen should be on the basis of the floating population cases and the previously untreated cases.