2006•Zhonghua zhongyiyao xuekanRequires access
Tang Ke Decoction to Kidney Pathological Effect of Diabetic Nephropathy Rat
Xiao Fu
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Abstract
Objective:To investigate and explore the effect of traditional Chinese medicine complex prescription-Tang Ke Decoction on early kidney pathological changes in experimental diabetic rat.Methods:78 male Wistar rats were divided into seven groups randomly.Rats in one group were given common forage.Rats in the other five groups were given high fat forage and were injected streptozotocin in vena caudalis once after one month to make diabetes and the blood stasis and phlegm syndromes in TCM model.Tang Ke Decoction with expelling phlegm and activating blood circulation was lavaged separatedly after success model and 4 weeks after success model.Luo Ting Xin group was control group of western medicine.The pathological changes of kidney were observed.Results: Tang Ke Decoction can lighten kidney hypertrophy and the renal glomerulus mesenterium ground substance hyperplasia and sclerosis;Tang Ke prevention group had obvious curative effect compared to tang Ke treatment group,which had significant difference.Conclusion:Chinese medicine complex prescription-Tang Ke Decoction can prevent and cure early diabetic nephropathy of rat which may have relationship with delaying the damages of kidney pathological changes.