Clinical significance of tissue MMP-3 expression in patients with colorectal carcinoma

Objective To,we investigate cancerous tissue MMP-3 expression in patients with colorectal carcinoma and evaluate its clinic significance.Methods Immunohistochemical method was used to detect tissue MMP-3 expression in 68 patients with colorectal carcinoma and its relationship with many pathologic parameters.Result Tissue MMP-3 expression was found to be significantly elevated in patients with colorectal carcinoma,compared with normal tissue(P0.05).There was a close relationship between tissue MMP-3 expression and the pathologic parameters such as presence of venous invasion,lymph node metastasis,liver metastasis and clinical-pathological stage(P0.05),but its relation to tumor site,histological type,age and sex was not significant(P0.05).Conclusions Tissue MMP-3 expression correlated significantly with biological behavior of colorectal carcinoma.the high expression of MMP-3 might be related with the occurrence and progress of colorectal cancer.