Expression and clinical siginificance of MMP-14 in colorectal carcinoma

Objective To investigate the expression and clinical siginificance of matrix metalloproteinase-14(MMP-14)in colorectal carcinoma.Methods The expression of MMP-14 was detected by Western blot in 8fresh human colorectal carcinoma and tumor-adjacent normal tissues,which was detected in paraffin-embedded specimens of cancer(90cases)and tumor-adjacent normal tissues(30cases).The relationship between the expression of MMP-14 and clinicopathological parameters of colorectal carcinoma was analyzed.Results The expression of MMP-14 in colorectal carcinoma was significantly higher than that in the tumor-adjacent normal tissues(P0.01).The expression intensity of MMP-14 protein was significantly correlated with the depth of tumor invasion,lymph node metastasis and Dukes classification of colorectal carcinoma(P0.05).The tumor histological grade,with or without lymph node metastasis,invasive depth,Dukes classification and MMP-14 expression were closely related with survival time(P0.05).MMP-14 expression was independent prognostic indicator for the prognosis of patients with colorectal carcinoma.Conclusion The high expression of MMP-14 is significantly related with the development and progression of colorectal carcinoma and MMP-14 may be used as an independent prognostic indicator for the patients with colorectal carcinoma.