The Protection of Telmisartan for the Function of Vascular Endothelium of Patients with Essential Hypertension

Objective To explore the protection of telmisartan for the function of vascular endothelium for patients with essential hypertension.Methods Fifty patients with essential hypertension were set as therapy group,took the telmisartan orally(40～80)mg/d for 12 weeks.Another 30 healthy people were chose as control group.Results After 12 weeks treated by telmisartan,the systolic and diatolic pressures of the patients in the therapy control were well controlled(P0.05 or P0.01).Before the treatment,the plasma level of VEGF、ET-1and vWF of patients of therapy group were significantly higher than that of control group,while the NO was oppsite(P0.01).After 12 weeks treatment by telmisartan,the level of VEGF、ET-1 and vWF of paitents of therapy group decreased significantly,and the level of NO rising significantly(P0.01).Conclusion Telmisartan can well descend the blood pressure,improve and protect the function of the vascular endothelium of the patients.