Influence on Telmisartan on Restraining Atherosclerosis and Its Efficacy to Control Hypertension

Objective To observe the efficacy of telmisartan on restraining atherosclerosis and its way to control hypertension. Methods The patients with EH(n=45) were treated with telmisartan 40mg, po, qd, for 31w. The patients with EH(n=43) were treated with Felodipine 5mg, po, qd, for 31w. Use color duplex sonography for evaluating extracoranial. Results The intima-media thickness, the delection rate of atherosclerosis plaque, and the incidence of carotid artery stenosis in CI group were significantly different from controls (P 0.01) .At the end of 1w, BP decreased significantly in patients with EH treated with telmisartan(P 0.01) , BP decreased continuously up to 31w. The total hypotensive rate of valsartan was 57% at 1w and 93% at 31w repectively. Conclusion Telmisartan has significant control on hypertension, restraining vascular endothelial function unusually and the reflection of membrane hyperplasia, protects vascular endothelium, improves reconstruction of vascular and restrains atherosclerosis.