The relationship between plasma homocysteine level and coronary heart disease

Objective To investigate the correlation between plasma homocysteine(HCY)level and coronary heart disease(CHD).Methods 117 patients with coronary heart disease(CHD group)and 50 healthy controls(control group)were involved in the investigation.Plasma total HCY level was measured with enzymatic cycling assay.According to the clinical types,CHD cases were divided into stable angina pectoris(SAP)group(n=35),unstable angina pectoris(UAP)group(n=39)and acute myocardial infarction(AMI)group(n=43).Based on coronary angiography,the CHD cases were further divided into single-vessel(n=31),double-vessel(n=40)and triple-vessel(n=46)groups.Results 1)Plasma HCY level was significantly higher in CHD group than that in control group(P0.01).2)Plasma HCY level was associated with clinical types,higherst in AMI group,followed by that of UAP group,SAP group,healthy control group.There was statistical difference of HCY level between SAP group and UAP group,SAP group and AMI group,UAP group and AMI group(P0.01).3)Plasma HCY level was gradually elevated in single-vessel,double-vessel and triple-vessel group.There was statistical difference of HCY level between single-vessel group or double-vessel group and triple-vessel group(P0.01).There was significant difference between single-vessel group and double-vessel group(P0.05).Conclusion Plasma HCY level is elevated in patients with CHD,and elevated HCY is associated with increased number of stenotic coronary arteries.As a risk factor for CHD,HCY is closely associated with the occurrence and development of CHD.