Study on relation between plasma level of homocysteine and coronary heart disease

Objective To study the relation between plasma total homocysteine(Hcy) and coronary heart disease(CHD).Methods Ninety three CHD patients were enrolled as CHD group and ninety four non CHD patients as control group.The plasma levels of Hcy were measured in all subjects.The relations between Hcy and cigarette smoking,diabetes,hypertension,age,sex,cerebral infarction,myocardial infarction,blood lipid were analyzed.Patients with ≥50% stenosis in one of the three coronary vessels in coronary angiography were assigned to single vessel group,patients with two and three coronary vessel stenosis were assigned to multiple vessel group and patients with 50% stenosis in one coronary vessel constituted the negative group.The data of conventional risk factors of CHD were analyzed with logistic regression.Results (1)The level of Hcy in the patients with CHD was higher than that in the control group.(2)Hcy level in the patients with MI was higher than that in non MI subjects.(3)There were no relations between Hcy and cigarette smoking,diabetes,hypertension,age,sex,cerebral infarction and blood lipid.(4)Hcy level in multiple vessel group was significantly higher than that in negative group.The single vessel group presented slightly higher Hcy level than negative group.(5) Hcy level,cigarette smoking and hypertension were risk factors of CHD.Conclusions Plasma Hcy level is elevated in patients with CHD,particularly in cases of MI.Higher level of Hcy is associated with increased number of coronary arteries with stenosis.