The Clinical Study of Dexamethasone and Mannitol for Acute Severe Cerebrovascular Disease Cerebral Protective Effect

Objective:To investigate the therapeutic effect of combination therapy with dexamethasone (DXM)and mannitol on acute severe cerebrovascular disease cerebral protective effect. Method:One hundred and sixty patients were randomly divided into the treatment group and the control group,the control group only received routine treatment with combination therapy,the treatment group was given DXM and mannitol on the basis of the control group. The indicators between the two groups were compared after treatment,such as the effective rate,complication. Result:ICP recovery time of the treatment group was significantly shorter than that of the control group after the treatment,but the difference of complications and mortality rate between the two groups in acute stage were no statistically significant (P0.05). The patients survived more than forty days of the control group was 34 cases while the treatment group was 73 cases after treatment,and the difference between the two groups were statistically significant (P0.05). Conclusion:DXM and mannitol is stronger in reducing brain edema,decreasing intracranial pressure cerebral protective effect in cerebrovascular disease,and does not increase the incidence of complication and mortality.