Effect of different doses of mannitol in patients with raised intracranial pressure

Objectives To evaluate the effect of different doses of mannitol on the patients of raised intracranial pressure and to observe the relationship between different doses of mannitol and sequent developing acute kidney failure.Methods We have collected 191 cases with raised intracranial pressure(GCS 6～10)divided randomly into three groups receiving the doses of mannitol 0.25g.kg 1 (n=63) 、0.5g.kg 1 (n=65)and 1.0g.kg 1 (n=63)respectively,the various effects and probability of sequent developing acute kidney failure in these three groups have be compared.Results The morbility of acute kidney failure is markedly relative to the doses of mannitol which patients were infused.Otherwise the effect of different doses of mannitol is variant.The effect is better in the mid-dose (0.5g.kg 1 )and the high-dose(1.0g.kg 1 )mannitol groups than in the low-dose group.Conclusions The present result indicates that the benefit effect is better in the mid-dose of mannitol group and the morbidity of acute kidney failure is lower than the high-dose group.