Expression of C-erbB-2?ER and PR in Primary Breast Carcinoma and Its Clinical Significance

Objective To investigate the expression of C-erbB-2?ER and PR and the relationships to the metastasis and prognosis of primary breast carcinoma. Methods The expression of C-erbB-2?ER and PR was detected by immunochemical s-p methods in 93 Cases of primary breast carcinoma. Results The expression of C-erbB-2?ER?PR were observed in 40.9%(38/93), 47.3%(44/93)?55.92%(52/93) respectively. The positive rates of C-erbB-2 increased with the number of metastasis lymph node and clinical stage, and there was a significant correlation(P0.05).The positive rates of ER and PR decreased with the number of metastasis lymph node and clinical stage. and there wasn't significant correlation(P0.05). ER and PR had a reverse correlation with the expression of C-erbB-2, but there wasn't significant difference(P0.05). Conclusions The C-erbB-2 is an useful prognostic factor in patients with breast carcinoma. The expression of ER and PR is associated with the clinical stage and lymph node metastasis of breast carcinoma, but the correlativity isn't significant. The combined detection of C-erbB-2?ER and PR has important significance for clinical therapy.