Expression of C-erBb-2,p53,ER and PR and prognosis in primary breast carcinoma

Objective To investigate whether C-erBb-2,p53,ER and PR are useful prognostic factors for patients with primary breast cancer. Method The expression of c-erbB-2, p53, ER and PR were detected immuno-chemically using monoclonal antibodies against them, in paraffin-embeded breast cancer tissue from 192 patients who had undergone axillary lymphadenectomy for mastectomy. The data were evaluated for any correlation with clin-icopathological indices. Results The expression of C-erbB-2, p53, ER and PR were observed in 39.1 % (75/192), 32.3%(62/192),47.9%(92/192),54.2%(104/192) of specimen respectively.The positive rates of c-erbB-2 and p53 increased with the number of metastatic and the clinicopathological stage, and there was a significant corre-lation(P0.05) .The expression of ER and PR had a reverse correlation with the expression of c-erbB-2 and p53, but there wasn' t significant difference( P 0.05). Furthermore, the co-expression of c-erbB-2 and p53 related to lymph node metastasis significantly ( P 0.05) . Conclusion These results indicated that c-erbB-2 and p53 are useful prognostic factors in patients with breast cancer. The expression of ER and PR are associated with the clinical stage and lymph node metastases of breast cancer,although this relation isn't significant.