The expression of C-erbB-2,p53,ER and PR in breast carcinoma and their clinical significance

Objective To study the expression of C-erbB-2,p53,ER and PR in breast carcinoma and their relationship with stages,metastasis and clinical significance.Methods The expression of C-erbB-2,p53,ER and PR was examined with immunohistochemical S-P technique in 83 cases of breast carcinoma.Results In 83 cases of breast carcinoma,the positive rate of C-erbB-2 was 36.1%(30/80),p53 was 37.3%(31/83),ER was 54.2%(45/83) ans PR was 63.9%(53/83).The expression of C-erbB-2 was positively correlated with p53(P0.05),and negatively correlated with ER and PR(P0.05).The expression rates of C-erbB-2 and p53 increased with increasing clinical stages and lymphatic metastasis,and there was significant difference(P0.05).The expression rates of ER and PR decreased with increasing clinical stages and decreasing lymphatic metastasis,with no significant difference(P0.05).The expression rates of ER and PR had negative correlation with the expression of C-erbB-2 and p53 and there was no significant difference(P0.05).Conclusions C-erbB-2 and p53 are useful prognostic factors in patients with breast carcinoma.The expression of ER and PR was associated with the clinical stage and lymphatic metastasis of breast carcinoma.The combined detection of C-erbB-2,p53,ER and PR has important significance for clinical therapy.