Expression of Survivin protein in tissues of cervical squamous cell carcinomas and its clinical significance

OBJECTIVE:To study the protein expression of Survivin in the tissues of cervical disease,and the changes and correlation between cervical squamous cell carcinomas(CSCC) and cervical intraepithelial neoplasia(CIN).METHODS: The protein expression of Survivin was examined by SP immunohistochemical stain(IHC) method in 92 tumors of CSCC,corresponding normal tissues and 40 CIN tissues,and the results were analyzed.RESULTS:The positive expression rates were 78.26%(72/92) in CSCC,and 26.67%(4/15),64.28%(9/14),72.72%(8/11) respectively in the CINⅠ,CINⅡ,CINⅢ groups.The positive expression rate was 2.17%(2/92) in corresponding normal tissues.The protein expressions of Survivin in CSCC,CINⅡ and CINⅢ were significantly higher than those in the CINⅠ group and the corresponding normal tissues(P0.01).The protein expression of CINⅠ was significantly lower than those in the CINⅡ and CINⅢ groups(P0.05).The Survivin expression was not correlated with age.CONCLUSION: The protein expression of Survivin is correlated with the progression of cervical cancer,histological graduation and clinical stages,but has no correlation with age.