Influence of hemoperfusion combined with continuous renal replacement therapy on inflammatory factors in patients with acute severe organophosphorus pesticide poisoning

Objective To explore the influence of hemoperfusion combined with continuous renal replacement therapy on the IL-4,TNF-α,IL-1β and other inflammatory factors in patients with acute severe organophosphorus pesticide poisoning.Methods Hospitalized patients admitted to and treated in our hospital meeting the diagnostic criteria for acute severe organophosphorus pesticide poisoning were divided into the treatment group and the control group.The serum IL-4,TNF-α and IL-1β levels before and after the treatment were detected and compared.Results After 12 hours of treatment,the IL-4 level of the treatment group decreased compared to that of the control group(P 0.05),and the TNF-α and IL-1β levels also decreased compared to those of the control group(P 0.01).After 24 hours of treatment,the TNF-α and IL-1β levels of the treatment group decreased compared to those of the control group(P all 0.05).Conclusion Through the elimination of inflammatory factors,hemoperfusion combined with continuous renal replacement therapy has provided a new method for the comprehensive clinical treatment of AOPP.