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2002•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access

Preparation and Quality Control of Tinidazole Buccal Film

Xin Yan

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Abstract

Aim To prepare a new buccal delivery system of tinidazole.Method Using CP934P?HPMC and NaAlg as the excipients,tinidazole buccal film was prepared,and its quality control was established.Result The content of tinidazole was determined by UV spectrophotometry at the wavelenth of 317nm,the linear range was 3.90～24.40μg·ml -1 ,the average recovery was 99.4% with RSD of 1.25%.Conclusion The tinidazole buccal film was good and its quality can be controlled.It is very suitable for preparation in hospital.

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What this paper is about

Aim To prepare a new buccal delivery system of tinidazole.Method Using CP934P?HPMC and NaAlg as the excipients,tinidazole buccal film was prepared,and its quality control was established.Result The content of tinidazole was determined by UV spectrophotometry at the wavelenth of 317nm,the linear range was 3.90～24.40μg·ml -1 ,the average recovery was 99.4% with RSD of 1.25%.Conclusion The tinidazole buccal film was good and its quality can be controlled.It is very suitable for preparation in hospital.

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Available abstract

Aim To prepare a new buccal delivery system of tinidazole.Method Using CP934P?HPMC and NaAlg as the excipients,tinidazole buccal film was prepared,and its quality control was established.Result The content of tinidazole was determined by UV spectrophotometry at the wavelenth of 317nm,the linear range was 3.90～24.40μg·ml -1 ,the average recovery was 99.4% with RSD of 1.25%.Conclusion The tinidazole buccal film was good and its quality can be controlled.It is very suitable for preparation in hospital.

Key concepts: Tinidazole, Buccal administration, Chromatography, Linear range, Materials science, Chemistry, Dentistry, Medicine

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