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Preparation and Quality Control of Compound Tinidazole Suppository

JI Huidi

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Abstract

OBJECTIVE:To prepare the compound tinidazole suppository and establish the quality control standard.METH_ODS:Taking S-40 as the base material and tinidazole,ofloxacin and nigoral as main ingredients,the compound tinidazole suppository was prepared.The UV-spectrophotometry was used for quantitative analysis.RESULTS:The average recovery rates of tinidazole,ofloxacin and nigoral were 98.10%、104.05% and 102.40%and their RSDs were 1.62%、1.33%and 0.68% respectively.CONCLUSION:The preparation of compound tinidazole suppository is easy in technological process.The method of content determination is simple and accurate.

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OBJECTIVE:To prepare the compound tinidazole suppository and establish the quality control standard.METH_ODS:Taking S-40 as the base material and tinidazole,ofloxacin and nigoral as main ingredients,the compound tinidazole suppository was prepared.The UV-spectrophotometry was used for quantitative analysis.RESULTS:The average recovery rates of tinidazole,ofloxacin and nigoral were 98.10%、104.05% and 102.40%and their RSDs were 1.62%、1.33%and 0.68% respectively.CONCLUSION:The preparation of compound tinidazole suppository is easy in technological process.The method of content determination is simple and accurate.

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Available abstract

OBJECTIVE:To prepare the compound tinidazole suppository and establish the quality control standard.METH_ODS:Taking S-40 as the base material and tinidazole,ofloxacin and nigoral as main ingredients,the compound tinidazole suppository was prepared.The UV-spectrophotometry was used for quantitative analysis.RESULTS:The average recovery rates of tinidazole,ofloxacin and nigoral were 98.10%、104.05% and 102.40%and their RSDs were 1.62%、1.33%and 0.68% respectively.CONCLUSION:The preparation of compound tinidazole suppository is easy in technological process.The method of content determination is simple and accurate.

Key concepts: Tinidazole, Suppository, Chromatography, Ofloxacin, Chemistry, Pharmacology, Medicine, Biochemistry

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