Effect of Simvastatin on blood lipid and plasma NO and NOS in patients with coronary artery disease

Objective Observe effects of Simvastatin on NO and NOS in plasma of patients with coronary heart disease.Methods 98 patients with coronary artery disease patients were randomly divided into conventional therapy group,Simvastatin group and therapeutic alliance group,adopt nitrate reductase for detecting plasma adiponectin and leptin levels before and after treatment.Results Eight weeks ago,there was no difference of NO and NOS levels in plasma of patients with coronary heart disease before treatment(F=4.86,3.53 P0.05).8 weeks later,there was a evident difference of NO and NOS levels in plasma of patients with coronary heart disease after treatment.NO and NOS levels in plasma of therapeutic(F=17.63,11.07 P0.05),alliance group increased significantly in therapeutic alliance group,followed by Simvastatin group and the conventional therapy group.Conclusion Simvastatin has beneficial effects on improving the impaired endothelium-dependent vasodilatation and increasing serum NO and NOS,and this may be one of mechanisms for the beneficial efects of simavastatin in prevention and treatment of CAD.