The efficacy of simvastatin for diabetes mellitus with coronary heart disease

Objective To observe the efficacy of simvastatin for diabetes mellitus with coronary heart disease. Methods 47 diabetic patients with coronary heart disease patients were chose to treat with oral simvastatin of 20mg once daily for 12 weeks. Before and after treatment, blood levels of sugar, lipids, nitric oxide( NO ), endothelin, and serum amyloid A protein( SAA )were detected, so was the function of vascular endothelial cells. Results After a 12-week therapy, levels of lipids and brachial arterial endothelium-dependent vasodilation were markedly improved, levels of ET and SAA declined and NO level elevated, with a statistical difference ( P < 0.05 and P < 0.01 ). Conclusions Simvastatin can protect endothelial function by reducing lipid levels and balancing the NO/ET ratio and play an anti-atherosclerotic role by lowering SAA levels. Key words: Diabetes mellitus;  Coronary heart disease;  Simvastatin;  Vascular endothelial function;  Blood lipids;  Blood sugar