Diagnostic and study status of sclerosing hemangioma of the lung

Objective To investigate the composition and histogenesis of sclerosing hemangioma of the lung(SHL),in order to elevate the recognition of clinicopathological feathers of SHL.Method The clinicopathlogical and immunohistochemical feathers were reviewed in 15 cases of SHL.Results SHL has a characteristic architecture composed of round cell and surface cubic cell.It has a variety of tissular structure,mainly expression with four regions that contains solid regions,papillary regions,angiomatoid regions and sclerosing regions.The expression of round cells about EMA,TTF-1,vimentin is positive and the expression of round cells about NSE,SYN,ER,PR is positive partly.As far as EMA,TTF-1 and SP-B are concered,the expression of surface cubic cell is positive.Conclusion Both solid round cells and surface cubic cells are neoplastic.SHL is a tumor that probably originates from the epithelial cell of primary respiratory tract.