Sclerosing hemangiomas of lung:a report of 2 cases and review of the literature

Objective:To investigate the features of sclerosing hemangiomas of lung(SHL) and improve diagnosis of SHL.Methods:Two cases of SHL were studied using routine histopathology(HE staining) and immunohistochemistry.Clinicopathological characteristics were then described and relevant literatures were reviewed.Results:Two cases were female.Tumors were solitary round or nearly round mass or nodule in lung.Under the microscope,four types of pathological manifestations,including papillary,solid,sclerolic and angiomatous,were found.The tumors consisted of two predominant cell types:pale polygonal cells and cuboid or columnar cells.Immunohistochemically,the cases were positive for cytokeretin,thyroid transcription factor and epithelial membrant antigen.Conclusions:SHL usually occur in female and is not easy to diagnosis clinically.It is suggested that SHL is an epithelial neoplasm derived from primitive respiratory epithelium.SHL have a characteristic appearance in microscopy and immunohistochemistry observation.