Effect of Zengshiling Oral Liquid on Gastrointestinal Motility of Young Rats

Objective To investigate the influence of Zengshiling oral liquid on gastric emptying,plasma motilin (MOT) and small intestine propulsion of young rat. Methods Experiment animal were divided into five groups randomly:control group,large dose of Zengshiling oral liquid group,normal dose of Zengshiling oral liquid group,small dose of Zengshiling oral liquid group and Motilium group. The rats were gavaged by 0.9% of NaCl and corresponding drug. 7 days later,gastric emptying was assayed by phenol red,plasma MOT levels and carbon powder propelling rate of small intestine were also assayed. Results The rate of gastric emptying of Zengshiling oral liquid groups were significantly higher than control group (P0.05). Except the Motilium group and the small dose of Zengshiling oral liquid group,the MOT content in other groups were notably higher than control group (P 0.05). The carbon powder propelling rate of Zengshiling oral liquid groups were significantly higher than control group (P 0.05 or P0.01). Conclusion Zengshiling oral liquid can obviously promote the rate of gastric emptying,raise the level of plasma MOT,and promote the small intestine propulsion of young rats. Its effect is related to the dosage.