2004•Chinese journal of integrated traditional and Western medicineRequires access
Effect of weichangshutai granule on gastric emptying and small intestinal propulsion in mice and motilin content in rats
Suli Wang, Pla No
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Abstract
Objective] To observe the effect of weichangshutai(WCST)granule on gastricemptying and small intestinal propulsion in mice and motilin (MOT) content in rats. [Methods] Half of the 100 ICR mice were used for gastric emptying experiment and another half for small intestinal propulsion. In each experiment the mice were randomly divided into 5 groups: control group, group of big dose, middle dose, small dose weichangshutai granule and cisaprade group. The effects of weichangshutai granuleon gastric emptying and small intestinal propulsionwere observed. Fifty SD rats were randomly divided into 5 groups. The effect of weichangshutai granule on motilin content of the rats was observed. [Results] The gastrointestinal emptying rate in big and middle dose of weichangshutai granule group was significantly higher than that of small dose group and control group. The content of MOT in big and middle dose group was significantly higher too. [Conclusion]Weichangshutai granule can promote the rate of gastrointestinal emptying and increase MOT content, the mechanism of which may be related with stimulating the release of endogenous MOT.