Efficacy of carvedilol in mild or moderate essential hypertension

? Objective To evaluate the efficacy of carvedilol in mild or moderate essential hypertension. Methods Sixty essential hypertension patients were randomly divided into carvedilol group (30 cases) and atenolol group (30 cases). Carvedilol (10～40mg) was given to carvedilol group once a day for 8 weeks. Atenolol (25～100mg) was given to atenolol group once a day for 8 weeks. Blood pressure and heart rate were measured and symptoms and signs were recorded. Results ①After treatment blood pressure was significantly decreased in both groups. The reduction of blood pressure was 28.3/20.1mmHg in carvedilol group and it was 23.5/16.9mmHg in atenolol group (compared with that before the treatment, P 0.01). There was no significant difference between these two groups ( P 0.05).②The overall efficacy rate for carvedilol therapy was 86.7%, and it was 76.7% in atenolol group. There was no significant difference between the two groups ( P 0.05 ).③After treatment the heart rate was also decreased in both groups (compared with that before the treatment, P 0.01). There was no significant difference between the two groups ( P 0.05). Conclusion The treatment with carvedilol can get good effects in mild or moderate essential hypertension, which shows that the carvedilol is an effective and safe anti hypertensive medicine.