Clinical study of carvedilol in treatment of mild to moderate essential hypertension

Objective To compare the anti-hypertension efficacy and the safety of 12.5-50 mg carvedilol for mild to moderate essential hypertension. Methods Sixty patients were enrolled in this clinical study.Patients randomly took 12.5-50 mg carvedilol tablet per day or 2.5-10 mg bisoprolol tablet per day for 24 weeks. Results The clinic blood pressure of the two groups decreased at the end of two weeks of treatment,and the decrease showed most significant at the end of 6-8 weeks of treatment.The blood pressure maintained the same level to the end of 24 week.The reduction of blood pressure was 19.7/11.4 mmHg in carvedilol group,compared with 16.6/9.1 mmHg in bisoprolol group.The overall efficacy rate of cavedilol therapy and hisoprolol therapy was 93.3% and 90%,respectively.The rate of significant efficiency was 70% and 56.7% in two groups,respectively.Carvedilol was well-tollerated with less side effects which included dizziness(13%),tiredness(2%),and drowsiness(2%).There were no patients withdrawing from the study because of side effects. Conclusions Carvedilol is effective and safe in patients with mild to moderate essential hypertension with a dose of 12.5-50 mg once per day as mono-therapy.