Comparison of different beta-blockers in treatment of mild to moderate essential hypertension

Objective To evaluate the efficacy and safety of bisoprilol/carvedilol in patients with mild or moderate essential hypertension.Methods A randomized,double-blind,parallel-controlled study was conducted to evaluate the efficacy and safety of bisoprilol/carvedilol in sixty out-patients with mild or moderate essential hypertension.Patients were randomly assigned to take 12.5～50 mg carvedilol tablets once daily or bisoprolol tablets 2.5～10 mg once daily for 24 weeks.Every 2 weeks,the dosage was increased if there was inadequate response.At each of two-week visits,sitting blood pressure and heart rate were measured in triplicate,adverse effects,symptoms and signs were recorded.Laboratory tests and electrocardiography were performed during the trial.Results ①The blood pressure began to decrease at the end of two weeks,markedly decreased at the end of 6～8 weeks,and maintained sure to the end of 24 week.② The reduction of blood pressure was 19.7/11.4 mmHg in carvedilol group,and 16.6/9.1mmHg in bisoprolol group.③The overall effectice rates for cavedilol and bisoprolol were 93.3% and 90%,respecticely.The rates of marked response were 70% and 56.7%,respectively,but there was no significant difference between the two groups(P0.05).④There were no effects on blood glucose,lipids,serum electrolytes,and hepatic and renal functions.Conclusion Both bisoprilol and carvedilol have favourable effects on delaying the progression of hypertension,and carvedilol shows better effects on preventing hypertension.Both bisoprilol and carvedilol have favourable tolerance and safety.