Correlation investigation of signal molecule CD_(40)/CD_(40L) and children asthma

Objective To explore correlation between the level of signal molecule CD_(40)/CD_(40L) and children asthma.Methods Twenty-five cases of attack asthmatic children,15 cases of stable asthmatic children and 20 cases of normal children were separately taken to test the percentage of CD_(40) and CD_(40L) on T and B lymphocytes in peripheral blood with flow cytometry,and it was compared a comparison of difference among three groups.Results (1) In expression rate of CD_(40) on B cells,attack asthma group [(17.90±3.36)%] was the highest,stable asthma group [(15.95±1.98)%] was higher than control group [(13.89±3.67)%],there was significant difference(P0.05),among three groups.(2)In expression rate of CD_(40L) on CD_4~+T cells,there was no significant difference(P0.05) between attack asthma group [(7.97±3.13)%] and stable asthma group [(8.05±2.75)%],which were all higher than control group [(5.58±3.00)%],there was significant difference(P0.05)separately compared to control group.(3)There was no difference(P0.05) among three groups in expression rate of CD_(40) on CD_4~+ and CD_8~+T cells.(4) There was no difference(P0.05) among three groups in expression rate of CD_(40L) on B lymphocyte and CD_8~+T cells.Conclusions Abnormal level of CD_(40)/CD_(40L) what attack asthma and stable asthma showed on their relevant immune cells would have an important significance in development of allergic asthma.